BDBM50131992 5-Bromo-3-[2-(4-fluoro-phenyl)-2-oxo-ethylidene]-1,3-dihydro-indol-2-one::CHEMBL127798

SMILES Fc1ccc(cc1)C(=O)\C=C1\C(=O)Nc2ccc(Br)cc12

InChI Key InChIKey=VVBIXEJMWRHSLL-MDWZMJQESA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50131992   

LigandPNGBDBM50131992(5-Bromo-3-[2-(4-fluoro-phenyl)-2-oxo-ethylidene]-1...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of human Cyclin-dependent kinase 1 cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50131992(5-Bromo-3-[2-(4-fluoro-phenyl)-2-oxo-ethylidene]-1...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, PfmrkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50131992(5-Bromo-3-[2-(4-fluoro-phenyl)-2-oxo-ethylidene]-1...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of Plasmodium falciparum 6His-tagged MRK expressed in Escherichia coli preincubated for 5 mins followed by [gamma32P]ATP addition by scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50131992(5-Bromo-3-[2-(4-fluoro-phenyl)-2-oxo-ethylidene]-1...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of Plasmodium falciparum cyclin-dependent kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50131992(5-Bromo-3-[2-(4-fluoro-phenyl)-2-oxo-ethylidene]-1...)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of Plasmodium falciparum cyclin dependent protein kinase, PfPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed