BDBM50135169 (-)-Catechin gallate::(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate::3,4,5-Trihydroxy-benzoic acid (2S,3R)-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester::CHEMBL129451

SMILES Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](Oc2c1)c1ccc(O)c(O)c1

InChI Key InChIKey=LSHVYAFMTMFKBA-CTNGQTDRSA-N

Data  4 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50135169   

TargetEnoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataKi:  40nMAssay Description:Inhibition of FabIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of FabZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-oxoacyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of FabG in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-oxoacyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of FabG in presence of acetoacetyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  1.28E+3nMAssay Description:Inhibition of 6PGDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity of the compound against recombinant human Beta-secretase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Plasmodium falciparum FabIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProteasome subunit beta type-5(Human)
Institute of Agricultural and Food Biotechnology

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  124nMAssay Description:Inhibition of chymotrypsin-like activity of purified human 20S proteasome assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-synuclein(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  220nMAssay Description:Inhibition of DYRK1A (unknown origin) using HT-497 as substrate preincubated with compound followed by substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  850nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Ser362, Ser205, Gly128, Lys207, Asp177, Hie84, Arg120, Ile51, Lys367 residuesMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  2.50E+3nMAssay Description:Antagonist activity at adrenergic alpha1A receptor in rat tail arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetGlucose-6-phosphate 1-dehydrogenase(Baker's yeast)
Amorepacific

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  240nMAssay Description:Inhibition of yeast G6PDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  400nMAssay Description:Inhibition of FabZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  300nMAssay Description:Inhibition of FabIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  2.50E+3nMAssay Description:Antagonist activity at adrenergic Alpha-1B receptor in guinea pig spleenMore data for this Ligand-Target Pair
In DepthDetails PubMed

Target3-oxoacyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of FabGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed