BDBM50135579 (S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-1-(2-hydroxy-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-3-(3,4-difluoro-phenyl)-2-methyl-propionamide::CHEMBL336813
SMILES C[C@@H](Cc1ccc(F)c(F)c1)C(=O)N[C@H]1N=C(c2ccc3OCOc3c2)c2ccccc2N(CCO)C1=O
InChI Key InChIKey=CFZFWNSAJHUAEM-YHAMSUFESA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 50135579
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair