BDBM50135832 (6-methylpyridin-2-ylamino)methylenediphosphonic acid::CHEMBL55959::[(6-Methyl-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acid::[[(6-methyl-2-pyridinyl)amino]methylene]-1,1-bisphosphonate

SMILES Cc1cccc(NC(P(O)(O)=O)P(O)(O)=O)n1

InChI Key InChIKey=PUHGLMILUJLANU-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50135832   

TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135832([[(6-methyl-2-pyridinyl)amino]methylene]-1,1-bisph...)
Affinity DataKi:  120nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135832([[(6-methyl-2-pyridinyl)amino]methylene]-1,1-bisph...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135832([[(6-methyl-2-pyridinyl)amino]methylene]-1,1-bisph...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibitory activity against Leishmania major Farnesyl-diphosphatesynthase (FPP synthase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50135832([[(6-methyl-2-pyridinyl)amino]methylene]-1,1-bisph...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed