BDBM50136383 (4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a]quinazolin-7-yl)(1-methyl-1H-imidazol-5-yl)methanamine::C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-tetrazolo[1,5-a]quinazolin-7-yl]-C-(3-methyl-3H-imidazol-4-yl)-methylamine::CHEMBL341586

SMILES Cn1cncc1C(N)(c1ccc(Cl)cc1)c1ccc2c(c1)c(nc1nnnn21)-c1cccc(Cl)c1

InChI Key InChIKey=XKBOADWPZLOLCO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50136383   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)

Curated by ChEMBL
LigandPNGBDBM50136383(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-tetrazo...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)

Curated by ChEMBL
LigandPNGBDBM50136383(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-tetrazo...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)

Curated by ChEMBL
LigandPNGBDBM50136383(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-tetrazo...)
Affinity DataIC50: 22nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)

Curated by ChEMBL
LigandPNGBDBM50136383(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-tetrazo...)
Affinity DataIC50: 461nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]GGPP into biotinYRASNRSCAIL peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)

Curated by ChEMBL
LigandPNGBDBM50136383(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-tetrazo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]GGPP into biotinYRASNRSCAIL peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed