BDBM50136586 CHEMBL138750::N-[3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenyl]-acetamide

SMILES C[C@H]1CN(CCc2ccccc2)CC[C@@]1(C)c1cccc(NC(C)=O)c1

InChI Key InChIKey=DSKWWUVQDXHXCE-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50136586   

TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136586(N-[3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4...)
Affinity DataIC50: 16nMAssay Description:Concentration required to inhibit agonist (loperamide) stimulated [35S]GTP-gamma-S, binding to membranes containing the cloned human mu opioid recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136586(N-[3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4...)
Affinity DataKi:  68nMAssay Description:Inhibition of binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136586(N-[3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity at cloned human kappa opioid receptor by [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed