BDBM50141074 6-{7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-indan-4-yl}-pyridin-2-ylamine::CHEMBL290875

SMILES CN1CCN(CCOc2ccc(c3CCCc23)-c2cccc(N)n2)CC1

InChI Key InChIKey=AARJQDPYTYPQGF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50141074   

TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141074(6-{7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-indan-4-...)
Affinity DataIC50:  3.03E+3nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141074(6-{7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-indan-4-...)
Affinity DataIC50:  2.20E+3nMAssay Description:In vitro inhibition of human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141074(6-{7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-indan-4-...)
Affinity DataIC50:  82nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141074(6-{7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-indan-4-...)
Affinity DataIC50:  123nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed