BDBM50142927 12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahydro-2H-2-pyranyl)-3,9-difluoro-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione::3,9-difluoro-12-(3,4,5-trihydroxy-6-hydroxymethyltetrahydro-2H-2-pyranyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione::CHEMBL290056

SMILES OCC1OC(C(O)C(O)C1O)n1c2ccc(F)cc2c2c3C(=O)NC(=O)c3c3c4cc(F)ccc4[nH]c3c12

InChI Key InChIKey=YQUUXCMYRDQFPL-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50142927   

TargetDNA topoisomerase 1(Human)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50142927(12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahy...)
Affinity DataEC50:  38.4nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed