BDBM50143661 8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL57546

SMILES Fc1ccc(cc1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1

InChI Key InChIKey=YSLMGFFVMWWPSA-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50143661   

TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50143661(8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Affinity DataKi:  14nMAssay Description:Binding affinity for human Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50143661(8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Affinity DataKi:  24.1nMAssay Description:Binding affinity to the adrenergic receptor alpha-1D of rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50143661(8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Affinity DataKi:  54nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50143661(8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Affinity DataKi:  91nMAssay Description:Binding affinity for rat Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50143661(8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Affinity DataKi:  153nMAssay Description:Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50143661(8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Affinity DataKi:  255nMAssay Description:Binding affinity for human Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50143661(8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Affinity DataKi:  620nMAssay Description:Binding affinity for human Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50143661(8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...)
Affinity DataKi:  2.20E+3nMAssay Description:Binding affinity for human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed