BDBM50146163 CHEMBL3764045

SMILES CNC(=O)c1cc2c(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)ccnc2cc1OC

InChI Key InChIKey=ORRNXRYWGDUDOG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50146163   

TargetPlatelet-derived growth factor receptor alpha(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of wild type human PDGFRalpha transfected with CHO cells by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 15nMAssay Description:Inhibition of AXL (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant VEGFR2 (805 to 1356 residues) in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged VEGFR-2 (unknown origin) using FL-Peptide 22 as substrate after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 32nMAssay Description:Inhibition of c-Met (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human Met using FLPeptide 2 as substrate after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 32nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant c-MET (956 to 1390 residues) expressed in Baculovirus infected Sf9 cell expression system by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed