BDBM50148921 CHEMBL3770443
SMILES CNc1ncc2cc(-c3ccc(cc3Cl)-c3cccc(C)n3)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1
InChI Key InChIKey=ZBCMHWUFWQFPLV-VVOJOOEHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50148921
Affinity DataKi: 3.70nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged PAK1 kinase domain (249 to 545 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:Inhibition of human recombinant PAK1 kinase domain using coumarin/fluorescein-labeled FRET peptide as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant KHS1More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant LCKMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant PAK2More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of GST-tagged human SIK2 autophosphorylation measured after 30 mins in presence of [gamma33P]ATP by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant YSK1More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of SIK2 (unknown origin) assessed as enzyme remaining activity by scanMAX kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.09E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant MST4More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant MST3More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of PAK1 in human EBC1 cells assessed as reduction in levels of MEK phosphorylation at S298 residue after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human SIK2More data for this Ligand-Target Pair