BDBM50149470 6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::6-(2-methoxyphenylthio)-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::CHEMBL331314

SMILES COc1ccccc1Sc1[nH]c2nc(N)nc(N)c2c1C

InChI Key InChIKey=WRYKYFPFYKSJNN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50149470   

TargetDihydrofolate reductase(Human pneumocystis pneumonia agent)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149470(6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 177nMAssay Description:Inhibition of Pneumocystis jirovecii recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149470(6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (Mycobacterium avium)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149470(6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 624nMAssay Description:Inhibition of human recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149470(6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149470(6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (Toxoplasma gondii)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149470(6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149470(6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149470(6-(2-Methoxy-phenylsulfanyl)-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of Dihydrofolate reductase from Pneumocystis carinii (Pneumocystis carinii)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed