BDBM50149602 CHEMBL3770239::US10273223, Compound A-10::US9637472, Compound A-10

SMILES CC(C)n1ncc2c(cc(nc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=MCFFAAQAYWQILI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50149602   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149602(CHEMBL3770239 | US10273223, Compound A-10 | US9637...)
Affinity DataIC50:  200nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149602(CHEMBL3770239 | US10273223, Compound A-10 | US9637...)
Affinity DataIC50: <300nMAssay Description:eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149602(CHEMBL3770239 | US10273223, Compound A-10 | US9637...)
Affinity DataIC50: <300nMAssay Description:Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent