BDBM50151605 4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-6-yl]phenyl-4-methylhexahydro-1-pyrazinylmethanone::CHEMBL183465

SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1

InChI Key InChIKey=UNFGOVWIPVJXET-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50151605   

LigandPNGBDBM50151605(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50151605(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant PDE7 (unknown origin) expressed in Escherichia coli BL21 (DE3) using [3H]cAMP as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50151605(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 1.70E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50151605(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant PDE4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50151605(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 7.01E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151605(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 2.93E+4nMAssay Description:Inhibition of human Phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151605(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 2.93E+4nMAssay Description:In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed