BDBM50154248 CHEMBL235851

SMILES COc1cc2ncnc(Nc3ccc(Cl)c(O)c3)c2cc1OC

InChI Key InChIKey=CEQUQTKEVIQAMX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50154248   

LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human recombinant RIPK2 (1 to 317 residues) expressed in Sf21 insect cells using MBP as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using PGT as substrate preincubated for 10 mins followed by substrate addition and measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Manchester

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 10nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 33nMAssay Description:Inhibition of human NOD1 expressed in HEK-Blue hNOD1 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of NF-kappaB tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Manchester

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Manchester

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 110nMAssay Description:Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based lumine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
TargetKinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET(Human)
University of Manchester

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 940nMAssay Description:Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NOD2 expressed in HEK-Blue hNOD2 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of TNF-alpha in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50154248BDBM50154248(CHEMBL235851)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NOD2 expressed in HEK-Blue hNOD2 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of NF-kappaB tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed