BDBM50154895 CHEMBL3775534::US10273244, Example 7::US10584135, Example 7

SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2cccc(c2)C#N)n1C

InChI Key InChIKey=QCALWRVXYCHRSG-UHFFFAOYSA-N

Data  10 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50154895   

TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  1.41nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  1.41nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  5.75nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  5.75nMAssay Description:Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  6.31nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  31.6nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  630nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataKi:  631nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
LigandPNGBDBM50154895(CHEMBL3775534 | US10273244, Example 7 | US10584135...)
Affinity DataIC50: 794nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed