BDBM50154958 CHEMBL3775910

SMILES CNC(=O)c1ccc2[nH]nc(Cc3cccc(C)c3)c2c1

InChI Key InChIKey=JMTPOBLXKZZYCU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50154958   

TargetCyclin-C(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50154958(CHEMBL3775910)
Affinity DataIC50: 170nMAssay Description:Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50154958(CHEMBL3775910)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed