BDBM50156069 CHEMBL365409::N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-methylbenzamide::N-(2,5-Diphenyl-2H-pyrazol-3-yl)-4-methyl-benzamide

SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1

InChI Key InChIKey=IQSIXTDPSJCEFA-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50156069   

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50156069(CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...)
Affinity DataKi:  780nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50156069(CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...)
Affinity DataEC50:  64nMAssay Description:Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50156069(CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...)
Affinity DataEC50:  40nMAssay Description:Effective concentration against metabotropic glutamate receptor 5 of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156069(CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...)
Affinity DataEC50:  30nMAssay Description:Effective concentration against metabotropic glutamate receptor 5 of human transfected into CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed