BDBM50157840 1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1)::1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione::CHEMBL361546

SMILES On1c(=O)n(CC2COc3ccccc3O2)c2ccsc2c1=O

InChI Key InChIKey=MXQGCMQXTPTJJT-UHFFFAOYSA-N

Data  3 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50157840   

TargetFlap endonuclease 1 [1-336](Human)
University of Sheffield

LigandPNGBDBM50157840(1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-...)
Affinity DataIC50:  46.4nMpH: 7.5Assay Description:Reaction mixtures containing twelve different concentrations of FAM-labeled DF1 (Supplementary Fig. 5a) substrate were prepared in reaction buffer (R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetFlap endonuclease 1(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50157840(1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-...)
Affinity DataIC50:  0.0110nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDNA excision repair protein ERCC-5(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50157840(1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-...)
Affinity DataIC50:  0.292nMAssay Description:Inhibitory concentration against the xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed