BDBM50158365 (Z)-6-(5-((1H-indol-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoic acid::5-(1H-indol-3-ylmethylene)-4-oxo-2-thioxo-3-thiazolidinehexanoic acid::6-(5-((1H-indol-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoic acid::CHEMBL222215

SMILES OC(=O)CCCCCN1C(=S)S\C(=C/c2c[nH]c3ccccc23)C1=O

InChI Key InChIKey=FEMGBXUNOYSLPO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50158365   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50158365((Z)-6-(5-((1H-indol-3-yl)methylene)-4-oxo-2-thioxo...)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta secretion pre-stimulated with P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPeptide deformylase(Escherichia coli)
Stine-Haskell Research Center

Curated by ChEMBL
LigandPNGBDBM50158365((Z)-6-(5-((1H-indol-3-yl)methylene)-4-oxo-2-thioxo...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Escherichia coli PDFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetEnoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
Institute of Science

Curated by ChEMBL
LigandPNGBDBM50158365((Z)-6-(5-((1H-indol-3-yl)methylene)-4-oxo-2-thioxo...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed