BDBM50160874 CHEMBL3794485::US9505736, (1S,2S,3S)-2-(4-(5- (Difluoromethoxy)pyrimidin-2-yl)phenyl)-1- fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide

SMILES ONC(=O)[C@]1(F)[C@@H]([C@H]1c1ccc(cc1)-c1ncc(OC(F)F)cn1)c1ccccc1

InChI Key InChIKey=RUTGGTYDBCHEPE-LZJOCLMNSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50160874   

TargetHistone deacetylase 4 [648-729,745-1057](Human)
Chdi Foundation

US Patent
LigandPNGBDBM50160874(CHEMBL3794485 | US9505736, (1S,2S,3S)-2-(4-(5- (Di...)
Affinity DataIC50:  40nMpH: 8.0 T: 25°CAssay Description:The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHistone deacetylase 4(Human)
Biofocus

Curated by ChEMBL
LigandPNGBDBM50160874(CHEMBL3794485 | US9505736, (1S,2S,3S)-2-(4-(5- (Di...)
Affinity DataIC50:  150nMAssay Description:Inhibition of HDAC4 in human Jurkat E6-1 cells using Lys-TFA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 4(Human)
Biofocus

Curated by ChEMBL
LigandPNGBDBM50160874(CHEMBL3794485 | US9505736, (1S,2S,3S)-2-(4-(5- (Di...)
Affinity DataIC50:  30nMAssay Description:Inhibition of HDAC4 catalytic domain (unknown origin) using Boc-Lys(TFA)-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed