BDBM50161956 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4-phenyl-thiazol-2-ylsulfanyl)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL367492::N-(4-(3-chloro-4-(4-phenylthiazol-2-ylthio)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(Sc4nc(cs4)-c4ccccc4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

InChI Key InChIKey=YAWRCBHLRDCILP-DHZHZOJOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50161956   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50161956(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50161956(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50161956(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4...)
Affinity DataIC50:  125nMAssay Description:Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed