BDBM50165871 CHEMBL3798635::US9550781, 13

SMILES CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F

InChI Key InChIKey=WCNKFDYACPTVPO-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50165871   

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50165871(US9550781, 13 | CHEMBL3798635)
Affinity DataIC50: 356nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50165871(US9550781, 13 | CHEMBL3798635)
Affinity DataIC50: 360nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50165871(US9550781, 13 | CHEMBL3798635)
Affinity DataIC50: 412nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetNuclear receptor coactivator 2 [740-753]()
Centaurus Biopharma

US Patent
LigandPNGBDBM50165871(US9550781, 13 | CHEMBL3798635)
Affinity DataIC50: 500nMAssay Description:In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50165871(US9550781, 13 | CHEMBL3798635)
Affinity DataEC50:  6.69E+3nMAssay Description:Inhibition of wild type B-Raf in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed