BDBM50165883 CHEMBL3797353

SMILES CCN(CC)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F

InChI Key InChIKey=QKCAIQUAPOMAIJ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50165883   

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50165883BDBM50165883(CHEMBL3797353)
Affinity DataIC50: 57nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50165883BDBM50165883(CHEMBL3797353)
Affinity DataIC50: 165nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50165883BDBM50165883(CHEMBL3797353)
Affinity DataIC50: 603nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50165883BDBM50165883(CHEMBL3797353)
Affinity DataEC50:  9.91E+3nMAssay Description:Inhibition of wild type B-Raf in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed