BDBM50168403 5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-2,4-difluoro-N-methoxy-benzamide::CHEMBL194498
SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
InChI Key InChIKey=BPXQYAXTDCQZHB-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50168403
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human protein kinase C alphaMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 840nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptor (HER-1)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human platelet-derived growth factor receptor betaMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cyclin-dependent kinase 2More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human fibroblast growth factor receptor 1More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human insulin-like growth factor I receptorMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition against human HER2 kinaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human p56 lck tyrosine kinaseMore data for this Ligand-Target Pair