BDBM50170202 4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide::CHEMBL181682

SMILES COc1ccc(cc1)-c1csc(c1)C(=O)NCCN1CCOCC1

InChI Key InChIKey=VWGKXDUPRHRCAO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50170202   

TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Matrix metalloproteinase-12 in pressence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed