BDBM50172868 (S)-2-(3-(benzyl(methyl)amino)propyl)-10,10a-dihydroimidazo[1,5-b]isoquinoline-1,3(2H,5H)-dione::(S)-2-[3-(Benzyl-methyl-amino)-propyl]-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione::CHEMBL1089752::CHEMBL365754

SMILES CN(CCCn1c(O)c2Cc3ccccc3Cn2c1=O)Cc1ccccc1

InChI Key InChIKey=WUNHBJWPQMYWSA-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50172868   

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50172868(CHEMBL365754 | (S)-2-[3-(Benzyl-methyl-amino)-prop...)
Affinity DataIC50: 3.90nMAssay Description:Displacement of [3H](+)-pentazocine from guinea-pig cerebral cortex sigma 1 receptor after 150 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172868(CHEMBL365754 | (S)-2-[3-(Benzyl-methyl-amino)-prop...)
Affinity DataIC50: 3.90nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172868(CHEMBL365754 | (S)-2-[3-(Benzyl-methyl-amino)-prop...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H](+)-pentazocine from human sigma 1 receptor in human Jurkat cell membranes incubated for 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172868(CHEMBL365754 | (S)-2-[3-(Benzyl-methyl-amino)-prop...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H](+)Pentazocine from sigma 1 receptor in human Jurkat cells after 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172868(CHEMBL365754 | (S)-2-[3-(Benzyl-methyl-amino)-prop...)
Affinity DataIC50: 650nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 opioid receptor in human Jurkat cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172868(CHEMBL365754 | (S)-2-[3-(Benzyl-methyl-amino)-prop...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 opioid receptor in human Jurkat cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed