BDBM50173222 (S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid::CHEMBL425020

SMILES COc1c(C)ccc2oc(C(=O)Nc3ccc(cc3)-c3ccc(cc3)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)c(C)c12

InChI Key InChIKey=PYNQNWZHEDOQHX-VWLOTQADSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50173222   

TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory concentration against MMP-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibitory concentration against Aggrecanase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  52nMAssay Description:Inhibitory concentration against MMP-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrilysin(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  534nMAssay Description:Inhibitory concentration against MMP-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  3.71E+4nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStromelysin-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  442nMAssay Description:Inhibitory concentration against MMP-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibitory concentration against MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50:  4.90nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed