BDBM50174714 (R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chloro-4-methoxyphenyl)acetamide::CHEMBL200629

SMILES COc1cc(\C=C\C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl

InChI Key InChIKey=JKAIKDYLOFOXMP-YXMGTMDOSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50174714   

TargetC-C chemokine receptor type 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174714((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  20nMAssay Description:Antagonistic activity at rat CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetC-C chemokine receptor type 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174714((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  4nMAssay Description:Antagonistic activity at human CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetC-C chemokine receptor type 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174714((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  50nMAssay Description:Antagonistic activity at mouse CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetC-C chemokine receptor type 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174714((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  70nMAssay Description:Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetC-C chemokine receptor type 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174714((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed