BDBM50175229 6-(4-amino-phenyl)-2,3,8,10-tetrahydro-1,4-dioxa-7,8-diaza-cyclohepta[b]naphthalen-9-one::6-(4-amino-phenyl)-2,3,8,10-tetrahyro-1,4-dioxa-7,8-diaza-cyclohepta[b]naphthalen-9-one::CHEMBL381673

SMILES Nc1ccc(cc1)C1=NNC(=O)Cc2cc3OCCOc3cc12

InChI Key InChIKey=XNRKEFPYLYWMAX-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175229   

TargetGlutamate receptor 2(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50175229(6-(4-amino-phenyl)-2,3,8,10-tetrahydro-1,4-dioxa-7...)
Affinity DataKi:  2.10E+4nMAssay Description:Antagonist activity at closed state of GFP-tagged GluA2Qflip isoform (unknown origin) expressed in HEK293S cells assessed as reduction in glutamate-i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50175229(6-(4-amino-phenyl)-2,3,8,10-tetrahydro-1,4-dioxa-7...)
Affinity DataKi:  3.30E+4nMAssay Description:Antagonist activity at open state of GFP-tagged GluA2Qflip isoform (unknown origin) expressed in HEK293S cells assessed as reduction in glutamate-ind...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50175229(6-(4-amino-phenyl)-2,3,8,10-tetrahydro-1,4-dioxa-7...)
Affinity DataIC50: >1.00E+4nMAssay Description:Ability to inhibit domoic acid-induced increase of calcium in rat HEK293 cells expressing GluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed