BDBM50175742 7-(8-aza-bicyclo[3.2.1]octan-3-yl)-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one::CHEMBL199701

SMILES Fc1ccc(c(Cl)c1)-c1cc(cc2n(-c3c(Cl)cccc3Cl)c(=O)ccc12)C1CC2CCC(C1)N2

InChI Key InChIKey=PULZCVVMWDBVFZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175742   

TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175742(7-(8-aza-bicyclo[3.2.1]octan-3-yl)-5-(2-chloro-4-f...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175742(7-(8-aza-bicyclo[3.2.1]octan-3-yl)-5-(2-chloro-4-f...)
Affinity DataIC50:  14.5nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175742(7-(8-aza-bicyclo[3.2.1]octan-3-yl)-5-(2-chloro-4-f...)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed