BDBM50175762 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)quinolin-2(1H)-one::CHEMBL369989

SMILES CC1(C)CC(=CC(C)(C)N1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1

InChI Key InChIKey=AFYPLGXAWPGZHZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175762   

TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175762(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175762(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50:  24.2nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175762(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50:  3.32nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed