BDBM50177125 6-(2-Chloro-4-fluoro-phenylsulfamoyl)-cyclohex-1-enecarboxylic acid ethyl ester::CHEMBL426184::ethyl 6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

SMILES CCOC(=O)C1=CCCCC1S(=O)(=O)Nc1ccc(F)cc1Cl

InChI Key InChIKey=LEEIJTHMHDMWLJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50177125   

TargetToll-like receptor 4(Homo sapiens (Human))
Baylor University

Curated by ChEMBL
LigandPNGBDBM50177125(6-(2-Chloro-4-fluoro-phenylsulfamoyl)-cyclohex-1-e...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human TLR4 expressed in HEK-Blue cells assessed as decrease in LPS-induced TLR4 response incubated for 1 hr followed by LPS stimulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Baylor University

Curated by ChEMBL
LigandPNGBDBM50177125(6-(2-Chloro-4-fluoro-phenylsulfamoyl)-cyclohex-1-e...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human TLR4-mediated cytokine production in mouse macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed