BDBM50179998 7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2H-1,2,4-triazol-3-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL373250
SMILES Cn1ncnc1COc1nn2c(nnc2cc1C(C)(C)C)-c1cc(F)ccc1F
InChI Key InChIKey=BQDUNOMMYOKHEP-UHFFFAOYSA-N
Data 10 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50179998
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKi: 0.670nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 expressed in Ltk cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp Laboratory
Curated by ChEMBL
Merck Sharp Laboratory
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha2 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha3 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Positive allosteric modulation of GABAA alpha3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKi: 0.790nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 expressed in Ltk cellsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha1 in combination with beta-3-gamma-2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta3gamma2 expressed in Ltk cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University of Sussex
Curated by ChEMBL
University of Sussex
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair