BDBM501810 4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p-tolyl-4,5- dihydro-pyrazin-2-yl]-3-fluoro- benzonitrile::US11028066, Example 48

SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1F)C#N

InChI Key InChIKey=IERXAPYUZDHLIF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501810   

TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501810(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50: 11nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501810(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501810(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50: 120nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed