BDBM50184074 (R)-N-(3-(3,5-dibromo-4-hydroxyphenyl)-1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl)-4-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidine-1-carboxamide::CHEMBL381585

SMILES O=C(N[C@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N1CCN(c2ccccc2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1

InChI Key InChIKey=DTYAISJWGQJWJI-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50184074   

TargetCalcitonin-gene-related peptide receptor, CALCRL/RAMP1(Human)
Department of Medicinal Chemistry Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50184074BDBM50184074((R)-N-(3-(3,5-dibromo-4-hydroxyphenyl)-1-oxo-1-(4-...)
Affinity DataIC50: 75nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin-gene-related peptide receptor, CALCRL/RAMP1(Human)
Department of Medicinal Chemistry Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50184074BDBM50184074((R)-N-(3-(3,5-dibromo-4-hydroxyphenyl)-1-oxo-1-(4-...)
Affinity DataKi:  83nMAssay Description:Displacement of [125I]CGRP from human cloned CLR/RAMP1 receptor expressed in E10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed