BDBM50184737 CHEMBL378563::N-(4-(trifluoromethyl)phenyl)-4-(3-(trifluoromethyl)pyridin-2-yl)benzamide

SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)cc1

InChI Key InChIKey=YOCQLGXBNLZHFA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50184737   

LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  3nMpH: 5.5Assay Description:Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  26nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity against capsaicin-activated human VR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed