BDBM50185000 CHEMBL3823844::US10351548, Compound SA16

SMILES Fc1ccc(Cn2cccc(C(=O)N[C@@H](C(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)c3ccccc3)c2=O)cc1F

InChI Key InChIKey=XCPMMIISBZJPHR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50185000   

TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant full length human His-tagged AURA expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 35nMAssay Description:Inhibition of Aurora A (unknown origin) by SelectScreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 416nMAssay Description:Inhibition of recombinant full length His-tagged human PDK1 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 416nMAssay Description:Inhibition of PDK1 (unknown origin) by SelectScreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
International Society For Drug Development

US Patent
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 416nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
US Patent

LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 416nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
International Society For Drug Development

US Patent
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50: 416nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed