BDBM50187779 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N1,N1-diethyl-N4-hydroxypiperidine-1,4-dicarboxamide::CHEMBL379287

SMILES CCN(CC)C(=O)N1CCC(CS(=O)(=O)c2ccc(OCC#CC)cc2)(CC1)C(=O)NO

InChI Key InChIKey=RBTIHKNARDNLNU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50187779   

TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187779(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N1,N1-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187779(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N1,N1-...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187779(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N1,N1-...)
Affinity DataIC50:  74nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50187779(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N1,N1-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187779(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N1,N1-...)
Affinity DataIC50:  345nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed