BDBM50187781 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(butylsulfonyl)-N-hydroxypiperidine-4-carboxamide::CHEMBL379763

SMILES CCCCS(=O)(=O)N1CCC(CS(=O)(=O)c2ccc(OCC#CC)cc2)(CC1)C(=O)NO

InChI Key InChIKey=MXMCYIBSFFNNTF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50187781   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187781(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(but...)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187781(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(but...)
Affinity DataIC50:  44nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187781(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(but...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187781(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(but...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed