BDBM50187786 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(thiophene-2-carbonyl)piperidine-4-carboxamide::CHEMBL211770

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)CC1(CCN(CC1)C(=O)c1cccs1)C(=O)NO

InChI Key InChIKey=WPYFTDWGMAINBU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50187786   

TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187786(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50:  257nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50187786(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50: <1nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187786(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187786(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187786(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50:  19nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed