BDBM50188608 CHEMBL209306::N-tert-butyl-N'-[2-(2,6-dimethylphenylamino)-5-nitrobenzenesulfonyl]urea

SMILES Cc1cccc(C)c1Nc1ccc(cc1S(=O)(=O)NC(=O)NC(C)(C)C)[N+]([O-])=O

InChI Key InChIKey=NHHSZFFUNUCPFW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50188608   

TargetThromboxane A2 receptor(Human)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50188608(N-tert-butyl-N'-[2-(2,6-dimethylphenylamino)-5-nit...)
Affinity DataIC50: 0.560nMAssay Description:Displacement of [3H]SQ-29548 from TPbeta receptor (long isoform) expressed in COS7 cells at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50188608(N-tert-butyl-N'-[2-(2,6-dimethylphenylamino)-5-nit...)
Affinity DataIC50: 0.780nMAssay Description:Displacement of [3H]SQ29,548 from TPalpha receptor (short isoform) expressed in COS7 cells at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50188608(N-tert-butyl-N'-[2-(2,6-dimethylphenylamino)-5-nit...)
Affinity DataIC50: 30.8nMAssay Description:Activity at TPbeta (long isoform) receptor expressed in HEK293 cells assessed as ability to antagonize U46619-mediated calcium ion mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50188608(N-tert-butyl-N'-[2-(2,6-dimethylphenylamino)-5-nit...)
Affinity DataIC50: 56.9nMAssay Description:Activity at TPalpha (short isoform) receptor expressed in HEK293 cells assessed as ability to antagonize U46619-mediated calcium ion mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
University of LièGe

Curated by ChEMBL
LigandPNGBDBM50188608(N-tert-butyl-N'-[2-(2,6-dimethylphenylamino)-5-nit...)
Affinity DataIC50: 90nMAssay Description:Inhibition of U46619-induced platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed