BDBM50189415 CHEMBL3828637

SMILES CNC(=O)c1ccc2cncc(-c3ccc4N(C)S(=O)(=O)Cc4c3)c2n1

InChI Key InChIKey=DFYVDBLGPYTIAT-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50189415   

TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50:  1.70nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-C(Human)
Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) measured after 1 hr by plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-C(Human)
Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50:  0.900nMAssay Description:Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)