BDBM50189744 (Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione::CHEMBL379156

SMILES Oc1cc(F)ccc1-c1ccc(\C=C2/SC(=O)NC2=O)o1

InChI Key InChIKey=OYYVWNDMOQPMGE-SDQBBNPISA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50189744   

LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MKK7betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human PI3Kgamma by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50:  940nMAssay Description:Inhibition of human PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Serono Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed