BDBM501929 US11028075, Example 62

SMILES Fc1cc(c(F)cc1N[C@H]1CC[C@@H](C[C@@H]1N1CCCCC1)c1cccc(c1)C(F)(F)F)S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=KPCRNIZNZGNYJE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 501929   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM501929(US11028075, Example 62)
Affinity DataIC50: 0.628nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM501929(US11028075, Example 62)
Affinity DataIC50: 0.816nMAssay Description:Saturation experiments. A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent