BDBM50193543 N-cyclopropylmethyl-14beta-(2'-chlorocinnamoylamino)-7,8-dihydronorcodeinone

SMILES COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(NC(=O)/C=C/c5ccccc5Cl)C(C2)N(CC2CC2)CC[C@]314

InChI Key InChIKey=DAGJGFYYIBDDIY-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50193543   

TargetMu-type opioid receptor(Guinea pig)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193543BDBM50193543(N-cyclopropylmethyl-14beta-(2'-chlorocinnamoylamin...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to MOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193543BDBM50193543(N-cyclopropylmethyl-14beta-(2'-chlorocinnamoylamin...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to KOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193543BDBM50193543(N-cyclopropylmethyl-14beta-(2'-chlorocinnamoylamin...)
Affinity DataEC50:  3.80nMAssay Description:Stimulation of [35S]GTPgammaS binding to human recombinant MORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193543BDBM50193543(N-cyclopropylmethyl-14beta-(2'-chlorocinnamoylamin...)
Affinity DataKi:  7.20nMAssay Description:Binding affinity to DOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193543BDBM50193543(N-cyclopropylmethyl-14beta-(2'-chlorocinnamoylamin...)
Affinity DataEC50:  9nMAssay Description:Stimulation of [35S]GTP-gamma-S binding to human recombinant KORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193543BDBM50193543(N-cyclopropylmethyl-14beta-(2'-chlorocinnamoylamin...)
Affinity DataEC50:  18nMAssay Description:Stimulation of [35S]GTP-gamma-S binding to human recombinant DORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed