BDBM50193711 CHEMBL3955846::US10478426, Example 36

SMILES COc1cccc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C

InChI Key InChIKey=PJZRSEKWQPTNFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50193711   

LigandPNGBDBM50193711(CHEMBL3955846 | US10478426, Example 36)
Affinity DataIC50: 2.50E+3nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193711(CHEMBL3955846 | US10478426, Example 36)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of wild-type EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex using HeLa cells der...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed