BDBM50193874 7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine::7-(2,6-dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine::CHEMBL436137::US8481536, 322

SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1

InChI Key InChIKey=YJSFAHMGDRBZGH-UHFFFAOYSA-N

Data  3 KI  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50193874   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataKi:  7nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataKi:  11nMAssay Description:Binding affinity to Abl (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetTyrosine-protein kinase ABL1(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataKi:  11nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  68nMAssay Description:Inhibition of Raf1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  20nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Blk(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of BlkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lck(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  13nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Fyn(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  23nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFibroblast growth factor receptor 1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  960nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-B receptor 4(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  64nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lyn(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  21nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  965nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAngiopoietin-1 receptor(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  678nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  555nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of YesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  5.99E+3nMAssay Description:Inhibition of Abl T315I mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 1A2(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  7nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  7nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  560nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  2.71E+3nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  6.80nMT: 25°CAssay Description:Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetTyrosine-protein kinase CSK(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50193874(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Affinity DataIC50:  659nMAssay Description:Inhibition of CSKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed