BDBM50194682 CHEMBL213478::N-methyl-6-(2-methyl-5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-ylamino)phenyl)quinazolin-2-amine

SMILES CNc1ncc2cc(-c3cc(Nc4nc5ccc(C(F)(F)F)cc5[nH]4)ccc3C)ccc2n1

InChI Key InChIKey=XDGHTBHPIPZHLJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50194682   

TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194682BDBM50194682(N-methyl-6-(2-methyl-5-(5-(trifluoromethyl)-1Hbenz...)
Affinity DataIC50: 277nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194682BDBM50194682(N-methyl-6-(2-methyl-5-(5-(trifluoromethyl)-1Hbenz...)
Affinity DataIC50: 297nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50194682BDBM50194682(N-methyl-6-(2-methyl-5-(5-(trifluoromethyl)-1Hbenz...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50194682BDBM50194682(N-methyl-6-(2-methyl-5-(5-(trifluoromethyl)-1Hbenz...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Jak3 by HTRF kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed