BDBM50195293 4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid::CHEMBL220153

SMILES CCC(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(O)=O

InChI Key InChIKey=VUJKPYBHOITRIE-HSUQSKAJSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50195293   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195293(4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin...)
Affinity DataKi:  120nMAssay Description:Inhibition of human truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195293(4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin...)
Affinity DataKi:  700nMAssay Description:Inhibition of mouse truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195293(4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of cortisol formation by fluorescent polarization immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195293(4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin...)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibition of human 11beta-HSD2 assessed as cortisol disappearance by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195293(4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of mouse 11beta-HSD2 assessed as cortisol disappearance by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed